William B. Grant, Ph.D.
Sunlight, Nutrition, and Health Research Center (SUNARC)
Table 1. Evidence by disease. Abbreviations:
Status: D, draft; (d), started, R, reviewed; S, submitted; ?, will omit during first round; PubM T&A as of Feb. 11, 2011, updated August 8, pubmed.gov, words in title and/or abstract; ecol, ecological studies, obser, observational studies, RCT, randomized controlled trial (or used in treatment with positive results); mod, moderate; assoc, effects of low vitamin D due to comorbid diseases or treatment.
Disease
|
Status
|
PubM
2-11
|
PM
8-8
|
Ecol
|
Obser
|
RCT
|
Strong
|
Mod
|
Weak
|
Assoc
|
Acne
|
D
|
14
|
15
|
X
|
||||||
Amyotrophic lateral sclerosis
|
S
|
7
|
7
|
X
|
||||||
Anaphylaxis, food allergy
|
RS
|
7
|
8
|
X
|
X
|
X
|
||||
Anemia
|
S
|
150
|
165
|
X
|
X
|
X
|
||||
Ankylosing spondylitis
|
D
|
22
|
22
|
X
|
||||||
Anxiety
|
D
|
26
|
30
|
X
|
||||||
Asthma
|
RS
|
106
|
134
|
X
|
X
|
X
|
||||
Atopic dermatitis, eczema
|
S
|
23
|
24
|
X
|
X
|
X
|
||||
Atherosclerosis
|
S
|
142
|
158
|
X
|
X
|
|||||
Autism
|
RS
|
18
|
21
|
X
|
X
|
X
|
||||
Bacterial vaginosis
|
S
|
5
|
7
|
X
|
X
|
|||||
Benign prostate hyperplasia
|
D
|
14
|
12
|
X
|
X
|
|||||
Biliary cirrhosis, primary (PBC)
|
D
|
99
|
101
|
X
|
X
|
|||||
Birth defects
|
?
|
6
|
6
|
X
|
Disease
|
PubM
2-11
|
PM*
8-8
|
Ecol
|
Obser
|
RCT
|
Strong
|
Mod
|
Weak
|
Assoc
|
|
15Bronchitis
|
?
|
2
|
2
|
|||||||
Cancer
|
RS
|
2321
|
2485
|
X
|
X
|
X
|
X
|
|||
Bladder
|
RS
|
43
|
21/43
|
X
|
X
|
|||||
Brain
|
D
|
17
|
0/19
|
X
|
X
|
|||||
Breast
|
RS
|
630
|
540/667
|
X
|
X
|
|||||
Cervical
|
S
|
17
|
9/18
|
X
|
||||||
|
S
|
228/339
|
||||||||
20Colorectal
|
S
|
391
|
244
|
X
|
X
|
|||||
Endometrial
|
S
|
27
|
18/29
|
X
|
X
|
|||||
Esophageal
|
S
|
14
|
6/17
|
X
|
X
|
|||||
Eye (uveal)
|
?
|
10
|
3/8
|
|||||||
Gallbladder
|
D
|
8
|
2/8
|
X
|
X
|
|||||
Gastric
|
RS
|
27
|
15/29
|
X
|
X
|
|||||
Head & neck
|
5/21
|
|||||||||
Hodgkin disease
|
S
|
27
|
X
|
X
|
||||||
Leukemia
|
S
|
301
|
306
|
X
|
X
|
|||||
Liver
|
?
|
55
|
3/59
|
|||||||
Lymphoma
|
94
|
|||||||||
Lung
|
RS
|
91
|
56/99
|
X
|
X
|
|||||
32Melanoma
|
RS
|
145
|
166
|
X
|
X
|
|||||
Multiple myeloma
|
S
|
57
|
61
|
X
|
X
|
|||||
Non-Hodgkin’s lymphoma
|
S
|
22
|
24
|
X
|
X
|
|||||
Non-melanoma skin
|
D
|
~70
|
16
|
|||||||
Ovarian
|
RS
|
85
|
60/94
|
X
|
X
|
|||||
Pancreatic
|
RS
|
56
|
43/60
|
X
|
X
|
|||||
Prostate
|
S
|
650
|
577/688
|
X
|
X
|
|||||
Rectal
|
S
|
30/65
|
||||||||
Renal
|
RS
|
120
|
6/121
|
X
|
X
|
|||||
Vulvar
|
?
|
1
|
0/2
|
X
|
X
|
* for cancer, the first number is a search using “vitamin D” and “breast cancer” while the second number is a search using “vitamin D”, “breast” and “cancer”
Disease
|
PubM
2-11
|
PM
8-8
|
Ecol
|
Obser
|
RCT
|
Strong
|
Mod
|
Weak
|
Assoc
|
|
42Cardiac arrhythmia
|
?
|
20
|
2
|
|||||||
Cardiovascular (disease)
|
RS
|
839
|
979
|
X
|
X
|
|||||
Celiac disease
|
D
|
80
|
86
|
X
|
||||||
Chronic kidney failure
|
S
|
563
|
627
|
X
|
X
|
|||||
Chronic liver disease
|
D
|
51
|
51
|
X
|
X
|
|||||
Chronic, diffuse muscle pain
|
?
|
20
|
?
|
|||||||
Chronic obstructive pulmonary disease
|
RS
|
41
|
48
|
X
|
X
|
|||||
Cognitive impairment
|
RS
|
26
|
28
|
X
|
X
|
|||||
50Common cold
|
D
|
X
|
X
|
|||||||
(Congestive) heart failure
|
RS
|
127
|
141
|
X
|
X
|
|||||
Coronary heart disease
|
RS
|
53
|
59
|
X
|
X
|
|||||
Craniotabes
|
D
|
19
|
20
|
|||||||
Cystic fibrosis
|
D
|
102
|
106
|
X
|
X
|
X
|
||||
Dementia
|
D
|
58
|
66
|
X
|
||||||
Dental caries
|
RS
|
36
|
36
|
X
|
X
|
X
|
||||
Depression
|
S
|
150
|
163
|
X
|
X
|
|||||
Diabetes, type 1
|
S
|
196
|
X
|
X
|
||||||
Diabetes, type 2
|
S
|
904
|
X
|
X
|
||||||
Diabetes
|
1006
|
|||||||||
60Epilepsy
|
D
|
90
|
100
|
X
|
X
|
X
|
||||
Fabry disease
|
?
|
3
|
3
|
|||||||
Falls, fractures (under osteoporosis)
|
(d)
|
116
|
263
|
X
|
X
|
X
|
||||
Fertility, regular menses
|
(d)
|
46
|
48
|
X
|
X
|
X
|
||||
Fibromyalgia
|
S
|
19
|
23
|
X
|
X
|
X
|
||||
Gaucher disease
|
?
|
6
|
6
|
|||||||
Headache, tension
|
D
|
16
|
16
|
X
|
X
|
|||||
Hepatitis
|
83
|
92
|
||||||||
HIV/AIDS
|
S
|
115
|
135
|
X
|
X
|
X
|
X
|
|||
Hypercalcemia
|
1175
|
1205
|
||||||||
70Hypertension
|
S
|
430
|
476
|
X
|
X
|
X
|
X
|
|||
Inflammatory bowel disease (Crohn’s disease, ulcerative colitis)
|
S
|
150
|
152
|
X
|
X
|
X
|
X
|
|||
Influenza
|
RS
|
37
|
42
|
X
|
X
|
X
|
X
|
|||
Insulin resistance
|
152
|
185
|
X
|
X
|
X
|
|||||
Kidney stones
|
43
|
44
|
X
|
|||||||
Learning (disorders)
|
?
|
0
|
21
|
|||||||
Leprosy
|
?
|
15
|
18
|
|||||||
Lupus
|
114
|
125
|
X
|
|||||||
Meningococcal dis., meningitis
|
S
|
0
|
4
|
X
|
X
|
|||||
Multiple sclerosis
|
RS
|
306
|
366
|
X
|
X
|
|||||
80Muscular weakness
|
146
|
X
|
||||||||
Myopathy
|
84
|
X
|
||||||||
Myositis
|
?
|
7
|
9
|
|||||||
Neutropenia
|
?
|
9
|
9
|
|||||||
Osteitis deformans
|
?
|
0
|
0
|
|||||||
Osteoarthritis
|
101
|
105
|
X
|
|||||||
Osteomalacia
|
D
|
1189
|
1198
|
|||||||
Osteopenia
|
652
|
678
|
||||||||
Osteoporosis
|
S
|
3302
|
3448
|
X
|
X
|
X
|
||||
Paget’s bone disease
|
S
|
74
|
58
|
X
|
X
|
X
|
||||
90Pancreatitis
|
36
|
39
|
||||||||
Parkinson’s disease
|
RS
|
36
|
43
|
X
|
X
|
|||||
Pelvic floor status
|
?
|
2
|
2
|
|||||||
Periodontal disease
|
RS
|
56
|
64
|
X
|
X
|
|||||
94Peripheral vascular disease
|
RS
|
9
|
12
|
X
|
X
|
|||||
Pneumonia
|
RS
|
30
|
37
|
X
|
X
|
X
|
||||
Polycystic ovary syndrome
|
D
|
13
|
18
|
X
|
X
|
X
|
||||
Preeclampsia
|
RS
|
29
|
38
|
X
|
X
|
|||||
Premature birth and low birth weight, birthweight
|
68
|
165
|
||||||||
Psoriasis, psoriatic arthritis
|
S
|
355
|
371
|
X
|
X
|
|||||
100Renal failure
|
803
|
822
|
||||||||
Renal osteodystrophy
|
341
|
344
|
||||||||
Respiratory tract infections
|
S
|
18
|
||||||||
Rheumatoid arthritis
|
214
|
222
|
X
|
X
|
||||||
Rickets
|
2110
|
2155
|
X
|
X
|
||||||
Rosacea
|
S
|
6
|
X
|
|||||||
Schizophrenia
|
68
|
73
|
X
|
X
|
||||||
Seasonal affective disorder
|
?
|
7
|
8
|
|||||||
Sepsis/septicemia
|
RS
|
34
|
40
|
X
|
X
|
X
|
||||
Sickle cell disease
|
17
|
20
|
X
|
|||||||
110Spinal stenosis
|
?
|
6
|
6
|
|||||||
Stroke
|
D
|
96
|
106
|
X
|
X
|
|||||
Systemic sclerosis
|
?
|
14
|
15
|
|||||||
Thalassaemia
|
14
|
16
|
||||||||
Thrombosis
|
?
|
31
|
32
|
X
|
X
|
|||||
Tonsillitis
|
S
|
2
|
2
|
X
|
||||||
Tuberculosis
|
243
|
259
|
X
|
X
|
X
|
|||||
Turner syndrome
|
?
|
5
|
5
|
|||||||
118Vitiligo vulgaris
|
?
|
3
|
27
|
None
|
||||||
Total, D or S
|
73
|
|||||||||
Started
|
2
|
|||||||||
Left to complete
|
21
|
|||||||||
Omit in first round
|
22 (?)
|
|||||||||
Disease
|
118
|
PubM
2-11
|
PM
8-8
|
Ecol
|
Obser
|
RCT
|
Strong
|
Mod
|
Weak
|
Assoc
|
Status: D, draft; R, reviewed; S, submitted; PubM T&A as of Feb. 11, 2011, pubmed.gov, words in title and/or abstract; ecol, ecological studies, obser, observational studies, RCT, randomized controlled trial (or used in treatment with positive results); mod, moderate; assoc, effects of low vitamin D due to comorbid diseases or treatment